Structure and Arterial Relaxing Activity of Substance P-related Peptides and Substance P analogs
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Opiate analogs, substance P, and baroreceptor reflexes in the rabbit.
The putative transmitters, enkephalins and substance P, and their binding sites have been identified in the nucleus of the solitary tract. Their role in the modulation of baroreceptor reflex activity is the subject of this study in the rabbit. A stable decarboxy analog of leu-enkephalin, RX 783016, which has mu receptor specificity, was used to attenuate the baroreflex sensitivity to intravenou...
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Skogh, A. 2018. Development of Substance P 1–7 Related Peptides and Peptidomimetics. Targeting Neuropathic Pain. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 249. 68 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0254-6. The neuropeptide substance P 1–7 (SP1–7, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH) and its amidated analogue SP1–7 amide, have di...
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on the response of bone alkaline phosphatase to parathyrin. The results of a typical experiment showing percentage change in alkaline phosphatase activity compared with the hormone-free control are presented in Fig. 2(b). Tissue from 1-day-old animals was unresponsive to parathyrin, that from the 3-day-old animal showed decreased alkaline phosphatase activity and those from 5and 6-day-old anima...
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The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg1, D-Trp7.9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7.9, Leu11]-substance P, but not by [D-Pro2, D-Trp7,9]-substance P. The profiles of protein...
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Communication between nerves and immune and inflammatory cells of the small and large intestine plays a major role in the modulation of several intestinal functions, including intestinal motility, ion transport, and mucosal permeability. Neuroimmune interactions at intestinal sites have been associated with the pathophysiology of infectious and enterotoxin-mediated diarrhea and intestinal infla...
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ژورنال
عنوان ژورنال: Korean Journal of Fisheries and Aquatic Sciences
سال: 2005
ISSN: 0374-8111
DOI: 10.5657/kfas.2005.38.3.143